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Arimidex Anastrozole/Treatment of Advanced Metastatic Breast Cancer in Postmenopausal Women


Arimidex Anastrozole/Treatment of Advanced Metastatic Breast Cancer in Postmenopausal Women

 

Description of Anastrozole

Anastrozole is a non-steroidal aromatase inhibitor and a third-generation aromatase inhibitor. It is clinically used to treat advanced metastatic breast cancer in postmenopausal women. Anastrozole can lower estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. Anastrozole is usually given to women whose cancer is not well controlled with tamoxifen (Nolvadex, Soltamox).

 

Anastrozole

Generic name: Anastrozole

Product name: Arimidex

Full Name: Arimidex, anastrozol, 阿那曲唑,瑞宁得,anastrozole

 

Indications of Anastrozole

1. It is suitable for the treatment of advanced breast cancer in postmenopausal women. For patients with negative estrogen receptors, if they have a positive  clinical response to tamoxifen, this product can be considered.

2. It is suitable for adjuvant therapy of hormone receptor positive early breast cancer in postmenopausal women.

3. It is suitable for the adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women who have received 2 to 3 years of  adjuvant tamoxifen therapy.

 

Dosage of Anastrozole

1. Once a day, 1 mg each time.

2. It can be taken in the morning or evening, before or after meals, and     swallow the whole medicine.

 

Side Effects of Anastrozole

Serious Adverse Reactions:

1. Skin reactions, such as skin lesions, ulcers or blisters.

2. An allergic reaction to swelling of the face, lips, tongue, or throat (which may cause difficulty swallowing or breathing).

3. Changes in liver function blood tests, including liver inflammation.Symptoms  may include general malaise, presence or absence of jaundice, liver pain, or   liver swelling.

 

Common adverse reactions in women (≥10%):

1. Hot flashes, fatigue, arthritis, pain

2. Arthralgia, high blood pressure, depression, nausea and vomiting

3. Rash, osteoporosis, fracture, back pain

4. Headache, bone pain, peripheral edema, aggravated cough

5. Dyspnea, pharyngitis and lymphedema, insomnia

Adverse reactions (>0.1%) of discontinuation of treatment in the trial:

hot flashes

 

Taboo

1. Hypersensitivity to anastrozole or any component of the preparation.

2. Pregnant women are prohibited.

3. Premenopausal women.

4. Patients with severe renal impairment (creatinine clearance less than 20ml/min).

 

Storage

Store at controlled room temperature, 20-25°C (68-77°F)

Keep away from light, sealed

 

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