Gonadorelin/Differential Diagnosis Male or Female Fertility Disorders
Gonadorelin/Differential Diagnosis Male or Female Fertility Disorders
Gonadorelin is mainly used in the differential diagnosis of male or female fertility disorders due to hypothalamic or pituitary hypofunction, gonadal atrophic hypogonadism, galactorrhea amenorrhea, primary and secondary amenorrhea, menopause, and precocious menopause , pituitary tumors, organ damage to the pituitary gland, and de facto hypothalamic dysfunction.
Dosage of Gonadorelin
Intravenous infusion: on the 2nd to 4th day of the cycle, 5-20 μg per minute for a total of 90 minutes. If there is no ovulation (measure basal body temperature), the drug can be re-administered; intramuscular injection of chorionic gonadotropin (HCG) after ovulation, 1500 units once, and 1500 units once every 3 days, usually after 2 to 4 cycles, pregnancy will occur.
Nasal cavity: For children with unilateral or bilateral cryptorchidism, the best treatment time is between 1 and 2 years old, 0.2mg once, 3 times a day (spray before breakfast, lunch, and dinner), and 4 weeks as a course of treatment . It can be used repeatedly after 3 months if necessary.
Subcutaneous or intravenous injection: ①For diagnosis: 100μg/time, women should be given as early as possible in the follicular phase of the menstrual cycle; ②Amenorrhoea, infertility: Give by pulse pump, each time 5-20μg within 1min, once every 90min, Use for 6 months or until pregnancy.
Indications
1. For the diagnosis of hypothalamic-pituitary-gonadal dysfunction.
2. Treatment of infertility caused by amenorrhea, insufficient secretion of gonadotropin and multi-follicular ovary.
3. Gonadorelin or its analogs buserelin, goserelin, leuprolide, nafarelin and triptorelin can also be used for contraception, cryptorchidism, malignant tumors (especially prostate cancer) , delayed and early puberty.
4. It can also be used for endometriosis.
5. It is used for ovulation induction to treat infertility and primary ovarian insufficiency caused by hypothalamic amenorrhea, especially for patients who are ineffective for clomiphene.
6. It is also used for cryptorchidism in children, androgen excess, and pituitary tumors.
Contraindications
1. People who are allergic to gonadorelin and breast-feeding are forbidden.
2. It is forbidden for patients with pituitary adenoma.
3. Women with polycystic ovary disease and endometriosis should not use gonadorelin.
4. Those who are allergic to benzyl alcohol are forbidden.
Adverse Reactions
1. Nausea, abdominal discomfort, headache, menorrhagia, vaginal dryness, flushing, loss of libido, etc. can be seen.
2. Pain, rash, thrombophlebitis, swelling and itching may occur at the injection site.
3. Allergic reactions have been reported, including bronchospasm and anaphylaxis.
4. There may be mental changes, nervousness, palpitations, acne, dry skin, changes in liver function tests and blood lipid measurements, impaired glucose tolerance, and changes in hair and body hair.
5. In the blood, when estrogen is suppressed for a long time, it may cause the bone density of trabecular bone to decrease.
6. Males may experience restlessness, hypofunction, breast swelling, and sensitivity to touch.
7. There may be multiple pregnancy, inflammation at the injection site, and occasional temporary penile hypertrophy.
Precautions
1. After the injection of this product, the LH peak appears successively, and then the FSH peak appears, and the LH peak is much stronger than the FSH peak. (1) Normal reaction: 25 minutes to 45 minutes after injection, the LH value rises to more than 3 times its base value, and the FSH value increases to more than 2 times. (2) Delayed response: LH reached its peak 120-180 minutes after injection. (3) Low and weak response: the peak value of LH after injection is only 2 times or less than 2 times of the base value. (4) No response: LH peak value remained unchanged or changed little before and after injection.
2. When administering the drug during the follicular phase of normal menstruation, contraceptive measures should be taken.
3. Patients using this product should not receive drugs that directly affect the secretion of gonadotropins from the pituitary gland at the same time.
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