Features and usage precautions for Procaine hydrochloride
Features and usage precautions for Procaine hydrochloride
Procaine hydrochloride description：
Procaine hydrochloride is a kind of drug, which acts on the conduction block of peripheral nerves, relying on concentration gradient to penetrate nerve cell membranes in a diffuse manner, block sodium ion channels in internal measurement, increase the excitation value of nerve cells, lose excitability and conductivity, block information transmission, and have good local anesthesia. Procaine hydrochloride is a white crystal or crystalline powder, odorless, slightly bitter, followed by a feeling of numbness, soluble in water, slightly soluble in ethanol, used for muscle anesthesia, the concentration of the solution is mostly 0.25% to 0.5%, not more than 1.5 grams per hour.
Procaine hydrochloride function：
The main role of procaine hydrochloride is to be used as local anesthesia, commonly used dosage forms include oral tablets and injections, due to different dosage forms, specifications, indications and usage, dosage is also different. For example, procaine hydrochloride tablets are oral dosage forms, mainly used to relieve neurasthenia, neurasthenic syndrome and autonomic dysfunction and other symptoms. Procaine hydrochloride injection as an injection form, generally used for anesthesia, such as infiltration anesthesia, tissue anesthesia, lumbar anesthesia, epidural anesthesia, partial occlusion therapy, etc., different dosage forms of procaine hydrochloride, the clinical role is not exactly the same.
Procaine belongs to the pharmacological effect of ester local anesthetic, which can play the role of anesthesia by blocking the conduction of nerve fibers, but the penetration of the skin and mucous membranes is weak, and surface anesthesia is usually not applicable. Procaine is relatively diffuse and permeable, and clinically it needs to be used reasonably under the guidance of doctors to detect related adverse reactions.
Procaine hydrochloride is suitable for people：
1. Pregnant and lactating women should be used with caution, if they must be used, they should be used appropriately according to the doctor's advice.
2. Children should use with caution, if they must be used, they should be used appropriately according to the doctor's advice.
3. The elderly have no special precautions, and the doctor should be informed before use.
4. Patients with liver injury: patients with mild to moderate liver injury should use with caution and should follow the doctor's advice to use an appropriate amount; It is forbidden to be used in severe hepatic insufficiency.
5. Patients with kidney injury should use with caution, if they must use it, they should be used appropriately according to the doctor's advice.
6. Others: decompensated respiratory insufficiency patients, myasthenia gravis, severe sleep apnea syndrome patients are banned.
Procaine hydrochloride dosage：
Procaine hydrochloride tablets: oral, two tablets a day (once taken or taken in two parts), taken continuously for 12 days as a course of treatment, discontinued for 18 days to continue taking the next course of treatment.
Procaine hydrochloride injection: infiltration anesthesia: 0.25%-0.5% aqueous solution, not more than 1.5g per hour. Blocking anesthesia: 1%-2% aqueous solution, not more than 1.0g per hour. Epidural anesthesia: 2% aqueous solution, not more than 0.75g per hour.
Adverse effects of procaine hydrochloride：
Procaine hydrochloride tablets: individual patients may experience dizziness, drowsiness, nausea or excitement.
Procaine hydrochloride injection: there will be hypersensitivity and allergic reactions, and individual patients will have methemoglobinemia; Too large a dose, too fast to absorb or straying into a blood vessel can cause a toxic reaction.
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Lauren
Hebei Uni-President Biopharmaceutical Co., Ltd.
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