Tianeptine/A Tricyclic Antidepressant
Tianeptine/A Tricyclic Antidepressant
Tianeptine is the sodium salt of tianeptine, a tricyclic antidepressant that acts on the serotonin system to play an antidepressant effect. It has been observed in animal experiments that tianeptine can increase the spontaneous activity of cone cells in the hippocampus, accelerate the recovery after functional inhibition, and accelerate the uptake of 5-HT by neurons in the cerebral cortex and hippocampus.
It has a certain effect on mood disorders. As a classification of antidepressants, this drug is a kind between sedative antidepressants and excitatory antidepressants. It has a significant effect on physical discomfort, especially gastrointestinal symptoms related to anxiety and mood disorders. It has a certain effect on the personality and behavioral disturbances of alcoholic patients during abstinence.
Dosage
The recommended dose is 3 times a day, 1 tablet at a time, orally before three meals (morning, noon, and evening).
For patients with chronic alcoholism, regardless of the presence of cirrhosis, no dose modification is necessary.
In patients over 70 years of age, and in patients with renal insufficiency, the dose should be limited to 2 tablets per day.
Adverse Reactions
Rare, usually not serious: Epigastric pain, abdominal pain, dry mouth, anorexia, nausea, vomiting, constipation, flatulence; insomnia, drowsiness, nightmares, weakness. Tachycardia, premature systole, precordial pain. Dizziness, headache, syncope, tremor, flushed face. Shortness of breath, throat congestion; myalgia, back pain.
Taboo
Those who are allergic to this product or any of the ingredients in this product; children under 15 years old are contraindicated; it is forbidden to combine with MAOI (monoamine oxidase inhibitor) drugs; before starting tianeptine treatment, MAOI drugs must be stopped for 2 weeks. However, patients who were originally taking tianeptine and changed to MAOI drugs only need to stop taking tianeptine for 24 hours.
Precautions
Depressed patients with hereditary suicidal tendencies must be closely monitored when taking this drug, especially at the beginning of treatment. If general anesthesia is required, the anesthesiologists should be informed that the patient is taking this drug, and the drug should be stopped 24 or 48 hours before the operation. When emergency surgery is required, there is no need for a drug withdrawal period, and preoperative monitoring is required. As with all psychiatric drugs, if the treatment is interrupted, the dose should be gradually reduced over 7-14 days. Effects on ability to drive or operate machinery Some patients experience decreased alertness. Therefore, drivers or machine operators should pay attention to the risk of drowsiness when taking this medicine.
Pharmacological Effect
Tianeptine is an antidepressant. In animals: increase the spontaneous activity of pyramidal cells in the hippocampus, and accelerate the recovery of its function after inhibition; increase the reabsorption of 5-hydroxytryptamine by neurons in the cerebral cortex and hippocampus. Characteristics of Tianeptine in the human body: It has a certain effect on mood disorders. As a classification of antidepressants, this drug is a kind between sedative antidepressants and excitatory antidepressants. It has a significant effect on physical discomfort, especially gastrointestinal symptoms related to anxiety and mood disorders. It has a certain effect on the personality and behavioral disturbances of alcoholic patients during abstinence. Tianeptine was free of the following adverse effects: sleep and alertness; cardiovascular system; cholinergic system (no anticholinergic symptoms); drug addiction.
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